The Postnatural Animal in Contemporary Art

The thesis uses art practice as a research method to propose novel characterisations of animal life. These characterisations aim to challenge an organicist image of non-human animals. The thesis considers animal bodies and behaviours as subject to aesthetic judgments that are underpinned by deeper ontological and epistemological commitments as to relations between nature and society, in which to be categorised as the former entails a series of privations in relation to the latter – the absence of freedom, subjectivity and creativity. Scholarly research on the history of the perception and conception of animal life within modernity, and subsequent challenges made to these within the contemporary humanities and contemporary art support and inform the practical enquiry. The thesis draws primarily here upon new materialist and post-humanist-oriented animal studies, and on scholarship surrounding the contemporary French artist, Pierre Huyghe. Positing the Anthropocene as a condition in which the distinction between human history and natural history has collapsed, the thesis argues for disassociating the concept ‘animal’ and the concept ‘nature’. The thesis attends to entanglements of animal worlds and cultural tropes where this equation fails. It proposes an an-organic and dis-harmonious animal life that attest to the end of nature and witnesses the dissonant and incomplete conditions of modernity. Both the written argument and the artistic outcomes propose novel ways to consider animals in relation to visuality. The thesis takes bio-art (i.e., art practice that incorporates living organisms) as of methodological value in this project where it engages the potentiality of animals themselves to challenge a received historical status. Furthermore, art practice is not just seen as a vehicle for depicting animal futures, but as a condition for liberating animals from nature. The thesis thus equates the postnatural animal with their becoming agents within artworks

The “Idea of Natural History” in the Work of Pierre Huyghe

In Theodor Adorno’s writing the term “natural history” has quite a different meaning to its usual scientific usage. Adorno’s idea of natural history aims at reconciling, in form and in content, the opposing forces of nature and history with the aim of overcoming the division of natural being and historical being that Adorno considered to be the central problem of critical social theory. Through sprawling installations the French contemporary artist Pierre Huyghe creates new forms of interaction between natural systems and artificial constructs. Huyghe’s body of work is submitted to interpretation through Adorno’s dialectic of nature and history to establish the relevance of both Huyghe’s practice and Adorno’s thought to the conditions of the Anthropocene

Characteristics of medical device software development

This paper aims to describe the software development settings of medical device domain focusing on the demands of the safety critical software processes. Medical device software developers have to adhere to a number of regulations and standards. This paper addresses the most important characteristics of a software development framework that could support medical device software developers in their efforts to comply with these regulations as well as to improve their software development processes

MDevSPICE - A comprehensive solution for manufacturers and assessors of safety-critical medical device software

Software development is frequently challenged with quality concerns. One of the primary reasons for such issues is the very nature of the software development process. First, it can be difficult to accurately and completely identify the requirements for a software development product. Also, the implementation on various platforms and the need to integrate with sometimes unforeseeable additional systems adds complexity. For safety critical domains, such as the medical device and healthcare sectors, these hurdles are amplified. Whereas a failure in a desktop application may be resolved through a restart with no harm incurred, a failure in a medical device can have life threatening consequences. Our work in the Regulated Software Research Centre (RSRC) aims to support medical device producers in the production of safer medical device software. In this paper, we describe the MDevSPICE framework and how it addresses the safety concerns faced by medical device producers

An exploration and critical analysis of the predisposing factors leading to depression within the British army

Depression is a common mental health (MB) disorder affecting British Army personnel and a significant factor in reducing the fighting capability of the British Armed Forces, yet as a theme it has not been the subject of a detailed empirical investigation. This thesis aimed to redress this imbalance by advancing knowledge and understanding of the predisposing factors that resulted in Army personnel presenting with Depression. Mixed research methods were utilised. Quantitative data was obtained from 2 survey questionnaires, the first providing information from 1,030 military MH hospital admissions and the second was completed by 317 serving soldiers. Qualitative information was obtained through interviews with 19 experienced Army MH clinicians and a Constructivist Grounded Theory provided the theoretical model. The most common reason why soldiers' required a MH hospital admission was for a depressive illness, with the majority presenting with multi-factorial problems displayed in a number of different ways, with the main causes being relationship problems, family issues and occupational stressors irrespective of rank, age and gender. The presentation of Depression was not uniform, or aligned to civilian definitions, and had a unique interpretation within the Army. Results draw attention to previously unpublished issues such as the plight of the unhappy young soldier, where nearly 50% of those who accessed the Army Medical Services (AMS) presented with the one stressor of wanting to leave the Army, and in this sample they were positively correlated with self-harming ideology. The results also challenge held beliefs such as soldiers with MH problems are stigmatised. Female soldiers were significantly more likely to attend for a MH assessment and to be admitted to hospital for a MH disorder, and were more prone to being diagnosed with Depression. It appeared that female soldiers were less affected by stigma, and GPs were more likely to refer a tearful woman than a man who disguised his emotions. The predisposing factors can be absorbed into 4 major clusters; situational stressors, maintaining / precipitating factors, secondary coping mechanisms and help seeking behaviour. There were issues related to the contextual differences of peacetime and operational duties; and the provision provided by the AMS, Departments of Community MH and Unit Command and these aspects could either enable or inhibit access to clinical support. These features are included within a theoretical model detailing the predisposing factors that influence the presentation of military depression and the patient's clinical pathway. This model can be utilised at a practical level within Primary Healthcare, also to support clinical education programmes, and to influence MOD policy. It is anticipated that the findings are transferable to other populations that deal predominately with men's MH, and Armed Forces in other countries

Towards a Critical Understanding of Music, Emotion and Self-Identity

The article begins by outlining a dominant conception of these relations in sociologically informed analysis of music, which sees music primarily as a positive resource for active self-making. My argument is that this conception rests on a problematic notion of the self and also on an overly optimistic understanding of music, which implicitly sees music as highly independent of negative social and historical processes. I then attempt to construct a) a more adequately critical conception of personal identity in modern societies; and b) a more balanced appraisal of music-society relations. I suggest two ways in which relations between self, music and society may not always be quite so positive or as healthy as the dominant conception suggests: 1) Music is now bound up with the incorporation of authenticity and creativity into capitalism, and with intensified consumption habits. 2) Emotional self-realisation through music is now linked to status competition. Interviews are analysed

Species classifier choice is a key consideration when analysing low-complexity food microbiome data

peer-reviewedBackground The use of shotgun metagenomics to analyse low-complexity microbial communities in foods has the potential to be of considerable fundamental and applied value. However, there is currently no consensus with respect to choice of species classification tool, platform, or sequencing depth. Here, we benchmarked the performances of three high-throughput short-read sequencing platforms, the Illumina MiSeq, NextSeq 500, and Ion Proton, for shotgun metagenomics of food microbiota. Briefly, we sequenced six kefir DNA samples and a mock community DNA sample, the latter constructed by evenly mixing genomic DNA from 13 food-related bacterial species. A variety of bioinformatic tools were used to analyse the data generated, and the effects of sequencing depth on these analyses were tested by randomly subsampling reads. Results Compositional analysis results were consistent between the platforms at divergent sequencing depths. However, we observed pronounced differences in the predictions from species classification tools. Indeed, PERMANOVA indicated that there was no significant differences between the compositional results generated by the different sequencers (p = 0.693, R2 = 0.011), but there was a significant difference between the results predicted by the species classifiers (p = 0.01, R2 = 0.127). The relative abundances predicted by the classifiers, apart from MetaPhlAn2, were apparently biased by reference genome sizes. Additionally, we observed varying false-positive rates among the classifiers. MetaPhlAn2 had the lowest false-positive rate, whereas SLIMM had the greatest false-positive rate. Strain-level analysis results were also similar across platforms. Each platform correctly identified the strains present in the mock community, but accuracy was improved slightly with greater sequencing depth. Notably, PanPhlAn detected the dominant strains in each kefir sample above 500,000 reads per sample. Again, the outputs from functional profiling analysis using SUPER-FOCUS were generally accordant between the platforms at different sequencing depths. Finally, and expectedly, metagenome assembly completeness was significantly lower on the MiSeq than either on the NextSeq (p = 0.03) or the Proton (p = 0.011), and it improved with increased sequencing depth. Conclusions Our results demonstrate a remarkable similarity in the results generated by the three sequencing platforms at different sequencing depths, and, in fact, the choice of bioinformatics methodology had a more evident impact on results than the choice of sequencer did.This research was funded by Science Foundation Ireland in the form of a centre grant (APC Microbiome Institute grant number SFI/12/RC/2273). Research in the Cotter laboratory is also funded by Science Foundation Ireland through the PI award “Obesibiotics” (11/PI/1137). Orla O’Sullivan is funded by Science Foundation Ireland through a Starting Investigator Research Grant award (13/SIRG/2160)

Colonic Gene Expression and Fecal Microbiota in Diarrhea-predominant Irritable Bowel Syndrome : Increased Toll-like Receptor 4 but Minimal Inflammation and no Response to Mesalazine

Background/Aims Diarrhea-predominant irritable bowel syndrome (IBS-D) has been previously associated with evidence of immune activation and altered microbiota. Our aim is to assess the effect of the anti-inflammatory agent, mesalazine, on inflammatory gene expression and microbiota composition in IBS-D. Methods We studied a subset of patients (n = 43) from a previously published 12-week radomized placebo-controlled trial of mesalazine. Mucosal biopsies were assessed by immunohistochemistry and reverse transcription-polymerase chain reaction for a range of markers of inflammation, altered permeability, and sensory receptors including Toll-like receptors (TLRs) at randomization after treatment. All biopsy data were compared to 21 healthy controls. Patient's stool microbiota composition was analysed through 16S ribosomal RNA sequencing. Results We found no evidence of increased immune activation compared to healthy controls. However, we did find increased expression of receptors in both sensory pathways and innate immune response including TLR4. Higher TLR4 expression was associated with greater urgency. TLR4 expression correlated strongly with the expression of the receptors bradykinin receptor B2, chemerin chemokine-like receptor 1, and transient receptor potential cation channel, subfamily A, member 1 as well as TLR4's downstream adaptor myeloid differentiation factor 88. Mesalazine had minimal effect on either gene expression or microbiota composition. Conclusions Biopsies from a well-characterized IBS-D cohort showed no substantial inflammation. Mesalazine has little effect on gene expression and its previous reported effect on fecal microbiota associated with much greater inflammation found in inflammatory bowel diseases is likely secondary to reduced inflammation. Increased expression of TLR4 and correlated receptors in IBS may mediate a general increase in sensitivity to external stimuli, particularly those that signal via the TLR system.Peer reviewe

Contract Modelling for Digital Business Ecosystems

The aim of this paper is to discuss the legal and technical issues of creating legally binding contracts in a digital ecosystem and to present the solution created for the DBE (Digital Business Ecosystem) project[1]. We investigate the legal implications of electronic contracts and digital signatures, and also take a brief look at the types of clauses that make up a contract. The DBE contract model for creating contracts and contract templates is presented, along with the tools created for editing these contracts as part of the DBE project

Getting It on Record: Issues and Strategies for Ethnographic Practice in Recording Studios

The recording studio has been somewhat neglected as a site for ethnographic fieldwork in the field of ethno-musicology and, moreover, the majority of published studies tend to overlook the specific concerns faced by the researcher within these contexts. Music recording studios can be places of creativity, artistry, and collaboration, but they often also involve challenging, intimidating, and fractious relations. Given that recording studios are, first and foremost, concerned with documenting musicians’ performances, we discuss the concerns of getting studio interactions “on record” in terms of access, social relations, and methods of data collection. This article reflects on some of the issues we faced when conducting our fieldwork within British music recording facilities and makes suggestions based on strategies that we employed to address these issues